Who Should I Start? Brandon Aiyuk or Cade Otton

Tuesday, December 2, 11:37 AM

San Francisco 49ers general manager John Lynch said he is "not sure" but "hopeful" when asked if it's realistic to expect wide receiver Brandon Aiyuk (knee) to take the field in 2025, per David Lombardi of The San Francisco Standard. Aiyuk tore multiple ligaments in his knee in Week 7 of the 2024 season and has yet to play in a game since. Aiyuk was one of the most efficient wide receivers in the NFL in the last full season he played back in 2023, recording 75 catches for 1,342 yards and seven touchdowns on 105 targets. However, it appears as though he may not be healthy until 2026. Aiyuk also may be locked into a contract stand-off with the team, as the 49ers reportedly voided guarantees in his current contract. Between the injury and the contractual issues, fantasy managers should likely proceed as though Aiyuk will not play a fantasy-relevant role in 2025.

Thursday, December 11, 7:30 PM

Tampa Bay Buccaneers tight end Cade Otton (knee), who was listed as doubtful for Week 15, has officially been ruled out for Thursday night's contest against the division-rival Atlanta Falcons. Otton suffered a knee injury in the Week 14 loss to the New Orleans Saints and will miss this week's game on a short week after missing practice Monday through Wednesday. The 26-year-old's next opportunity to play will come in Week 16 versus the division-rival Carolina Panthers on Sunday, Dec. 21. With Otton sidelined on Thursday night, Payne Durham and Devin Culp figure to share snaps at the TE position for the Bucs. Fantasy managers should be looking to avoid the Bucs' TE situation with Otton out this week. Otton has recorded 46 receptions for 430 yards and no touchdowns on 66 targets through 14 weeks in 2025.