Who Should I Start? Brandon Aiyuk or Darnell Mooney

Wednesday, November 26, 3:44 PM

The San Francisco 49ers will not open the 21-day practice window for wide receiver Brandon Aiyuk (knee) this week, according to head coach Kyle Shanahan. The same goes for fellow wideout Jacob Cowing (hamstring). A report surfaced last week that the 49ers voided guarantees in Aiyuk's four-year contract extension, which could lead to the 27-year-old former first-rounder sitting out the entire 2025 campaign. If that happens, the 49ers would likely release him at season's end. Fantasy managers who have been stashing Aiyuk all season long might not get to use him at all. It's good news for the rest-of-season outlooks for both Jauan Jennings and Ricky Pearsall, as well as tight end George Kittle. Aiyuk has been recovering from his season-ending injury last year, in which he tore both his ACL and MCL.

Sunday, November 23, 10:12 PM

Atlanta Falcons wide receiver Darnell Mooney made an immediate impact with Drake London (knee) out in the team's Week 12 win over the New Orleans Saints on Sunday. Although Mooney only had three targets in the 24-10 victory on the road, he made his three receptions count, leading the team with 74 receiving yards and finding the end zone for the first time in 2025. The 28-year-old's 74 yards were also a season high. Efficiency could be a problem going forward with quarterback Kirk Cousins taking over for the injured Michael Penix Jr. (knee) for the rest of the year, but Mooney could have more opportunities as Atlanta's WR1 with London dealing with a PCL sprain. London is considered week-to-week and could miss the team's Week 13 contest against the New York Jets. Coming into Sunday's game, Mooney had exactly one catch in three of the last four contests. However, he'll be in play again next week as a WR4/flex in fantasy if London misses a second straight game.