Who Should I Start? Brandon Aiyuk or Marvin Harrison Jr.

Wednesday, November 26, 3:44 PM

The San Francisco 49ers will not open the 21-day practice window for wide receiver Brandon Aiyuk (knee) this week, according to head coach Kyle Shanahan. The same goes for fellow wideout Jacob Cowing (hamstring). A report surfaced last week that the 49ers voided guarantees in Aiyuk's four-year contract extension, which could lead to the 27-year-old former first-rounder sitting out the entire 2025 campaign. If that happens, the 49ers would likely release him at season's end. Fantasy managers who have been stashing Aiyuk all season long might not get to use him at all. It's good news for the rest-of-season outlooks for both Jauan Jennings and Ricky Pearsall, as well as tight end George Kittle. Aiyuk has been recovering from his season-ending injury last year, in which he tore both his ACL and MCL.

Thursday, November 27, 11:12 PM

Arizona Cardinals wide receiver Marvin Harrison Jr. (appendix) was limited again in Thursday's practice. He was limited for a second straight day and is trending in the right direction to suit up for Sunday's game against the Tampa Bay Buccaneers. The 23-year-old has missed the last two games after undergoing an appendectomy following Week 10. He has caught 34 of 62 targets for 525 yards and four touchdowns over nine games in 2025. Harrison will have one more chance to log a full practice, but will likely carry an injury designation heading into Week 13. If Harrison is unable to suit up, look for Michael Wilson and Greg Dortch to see another uptick in targets and snaps with Harrison sidelined.