Who Should I Start? Christian McCaffrey or Isaac Guerendo

Thursday, February 5, 5:06 PM

San Francisco 49ers running back Christian McCaffrey was named the 2025 Comeback Player of the Year on Thursday night, according to Matt Barrows of The Athletic. McCaffrey was limited to only four games in 2024 due to Achilles and knee issues, but he played in all 17 regular-season games in 2025 and led the 49ers in both rushing (1,202) and receiving yards (924). The four-time Pro Bowler and three-time first-team All-Pro handled a career-high 311 carries and scored 10 rushing touchdowns while also catching 102 passes on 129 targets with an additional seven trips to the end zone as a receiver. The Offensive Player of the Year in 2023 was the RB1 in half-PPR fantasy scoring this year after he slipped to the late first round of many drafts following his injury-plagued 2024 campaign. CMC is entering his age-30 campaign and has a lengthy injury history, but it's simply too hard to ignore his game-changing dual-threat abilities out of the backfield as the engine of San Fran's offense.

Monday, December 22, 7:11 PM

San Francisco 49ers running back Jordan James is active for Monday's Week 16 contest against the Indianapolis Colts and is on track to make his NFL debut. The rookie had previously been a healthy scratch, but he's getting a chance to play on primetime television, perhaps in a mix of special teams and offensive depth roles. He's taking the spot of fellow rookie Isaac Guerendo, who is a healthy scratch for the first time in his young career. Guerendo has contributed on special teams this year, but he doesn't have an offensive snap yet. Both running backs remain buried on the depth chart behind Christian McCaffrey and Brian Robinson Jr.