Who Should I Start? Christian McCaffrey or Isaac Guerendo

Sunday, November 16, 8:42 PM

San Francisco 49ers running back Christian McCaffrey had 13 carries for 81 rushing yards and two rushing touchdowns during Sunday's Week 11 win over the Arizona Cardinals. He also caught five of his six targets for an additional 40 receiving yards and one receiving touchdown. The superstar running back continues to demonstrate excellence as a rusher and receiver, and his big game officially propelled him past Jonathan Taylor for the overall RB1 spot (PPR) through 11 weeks. Given that he was a late-first-round pick in most redraft leagues this year, managers are getting even more than they expected from the 29-year-old. He remains a must-start RB1 for Week 12 against his old team, the Carolina Panthers.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.