Who Should I Start? Christian McCaffrey or Isaac Guerendo

Tuesday, December 2, 4:21 PM

San Francisco 49ers running back Christian McCaffrey handled 20 carries for 53 yards and a touchdown in the team's 26-8 win over the Browns in Week 13. He also caught all four of his targets for 21 receiving yards. Sunday's game was just the third time this season that McCaffrey finished with fewer than 100 scrimmage yards, and his four targets were a season low. Still, the two-time All-Pro finished as a top-12 running back in PPR scoring for the twelfth time in 13 weeks. Fantasy football managers will have to do without McCaffrey's services in Week 14 while the 49ers are on bye. Those lucky enough to have sewn up a spot in the fantasy football playoffs get to look forward to a matchup against the Titans in Week 15.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.