Who Should I Start? Christian McCaffrey or Isaac Guerendo

Friday, May 9, 12:06 PM

San Francisco 49ers offensive coordinator Klay Kubiak said that running back Christian McCaffrey (knee) "looks awesome" this offseason and also said that "we're going to do everything we can to get him the ball as much as we can." McCaffrey was a big-time fantasy bust as the No. 1 overall pick in most fantasy drafts in 2024, as he didn't make his season debut until Week 10 due to bilateral Achilles tendinitis before spraining his PCL in Week 14 and being shut down for the rest of the year. The 28-year-old All-Pro has no restrictions during the team's offseason program, though, and should be fully healthy for Week 1 in 2025. It doesn't sound like the Niners plan to reduce his workload this year, but fantasy managers are surely skeptical about CMC staying healthy for a full season. McCaffrey is a league-winner if he stays healthy, but he's played fewer than eight games three times in the last five years.

Monday, January 6, 10:31 PM

An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.