Who Should I Start? Christian McCaffrey or Jonathan Taylor

Sunday, September 7, 10:07 AM

San Francisco 49ers running back Christian McCaffrey (calf) did not practice on Friday, but he was a "big participant in the walkthrough on Saturday," according to NFL Network's Ian Rapoport. As a result, the star running back is trending toward playing. Fantasy managers are holding their breath and hoping that McCaffrey avoids a repeat of the 2024 season when he was expected to be healthy for Week 1 but then ultimately missed the first nine games. We'll get confirmation on his status around 2:35 p.m. ET when the 49ers post their list of inactive players. If McCaffrey does suit up against the Seahawks, he'll rank as a mid-range RB1 in fantasy football.

Saturday, September 6, 7:45 AM

Indianapolis Colts running back Jonathan Taylor will open his 2025 season with a home matchup against the Miami Dolphins. Taylor finished his 2024 season on a tear, scoring six touchdowns over the final three games of the year. He will look to get off to a fast start this season against a Miami defense that allowed the 18th-most fantasy points per game to opposing running backs. Thanks to the Colts' decision to go with Daniel Jones over Anthony Richardson Sr. at quarterback, Taylor should see more targets and more carries at the goal line than he would if Richardson were available. Taylor checks in as a top-six, must-start fantasy option heading into the first week of games.