Should I Start Christian McCaffrey?

Friday, September 25, 2:53 PM

San Francisco 49ers running back Christian McCaffrey has the opportunity to bounce back when his team hosts the Arizona Cardinals in Week 3. The star back was part of a large contingent of players who didn't participate in Wednesday's practice but returned on Thursday to prepare for Sunday's divisional matchup. McCaffrey was held to 23 yards on 10 carries in Week 2 but scored two rushing TDs in a convincing 35-13 win against the Miami Dolphins. Arizona has struggled to contain the run early in the 2026 campaign, allowing 243 yards and one touchdown on the ground through two games. CMC should be able to exploit the Cardinals' defense, setting the table for a strong Week 3 across fantasy leagues.