Who Should I Start? Isaac Guerendo or Jaydon Blue

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Friday, November 28, 10:35 PM

Dallas Cowboys rookie running back Jaydon Blue impressed the coaching staff in training camp and the preseason, leading to him being a late-round dart throw in fantasy football drafts. Blue has been unable to carry over that momentum during the summer into his first NFL season, though, as he's been active for only four games in 2025. The 21-year-old fifth-round selection out of Texas didn't make his debut until Week 5, and he has been a healthy scratch in four consecutive games since he fumbled the ball away in the team's Week 8 loss to the Denver Broncos. It seemed as though Blue had a clear path to RB2 duties after Miles Sanders had season-ending knee surgery, but Malik Davis has ascended the depth chart behind starter Javonte Williams instead. In his four games this year, Blue has only 22 carries for 65 yards (3.0 yards per carry) and no touchdowns. Blue should only be stashed in keeper/dynasty leagues.