Who Should I Start? Isaac Guerendo or Jaydon Blue

Wednesday, September 17, 12:37 PM

San Francisco 49ers running back Isaac Guerendo entered the 2025 season as a prime handcuff for fantasy managers who were looking to score Christian McCaffrey at a discount early in drafts. However, Guerendo's fantasy value took a massive hit when the Niners acquired Brian Robinson Jr. from the Washington Commanders. B-Rob has been McCaffrey's backup through two weeks, relegating Guerendo to a distant RB3 role. In the Week 2 win over the New Orleans Saints, the 25-year-old didn't play a single snap on offense, with all 17 of his snaps coming on special teams. Guerendo averaged a healthy 5.0 yards per carry on 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) as a rookie in 2024 when CMC was bothered by injuries, but currently, he's well off the fantasy radar in single-year leagues going into Week 3 against the division-rival Arizona Cardinals.

Sunday, September 14, 11:48 AM

Dallas Cowboys running back Jaydon Blue (coach's decision) is inactive for Sunday's Week 2 contest against the New York Giants. The fifth-round rookie has now been a healthy scratch for each of the Cowboys' first two games of the season. In his absence, Miles Sanders will serve as the backup running back behind Javonte Williams. Sanders and Williams are the Cowboys' only two active running backs, but fullback Hunter Luepke should also see some blocking work in the backfield. Fantasy managers in deeper leagues should be patient with Blue and hold onto him, as it's likely only a matter of time before he's active as the No. 3 running back or leapfrogs Miles Sanders for the backup job.