Who Should I Start? Joe Mixon or Omarion Hampton

Thursday, November 20, 12:34 PM

Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

Friday, November 28, 4:31 PM

Los Angeles Chargers rookie running back Omarion Hampton (ankle) has officially been ruled out for Sunday's game against the Las Vegas Raiders, according to Alex Insdorf of the Bolt Beat. Hampton has been sidelined since Week 5, and it was recently reported that he was dealing with a fractured ankle. The rookie first-rounder was listed as limited every day in practice this week, and will need at least another week before he's ready to go. It's also possible that Hampton operates in a timeshare with second-year back Kimani Vidal when he returns, as indicated by offensive coordinator Greg Roman. That could limit the rookie's rest of season upside, but he was producing at a high level before going down with injury, recording 66 carries for 314 yards and two touchdowns along with 20 receptions (22 targets) for 136 yards as a receiver. Vidal is in line to handle the bulk of the touches again in Week 13 against the Raiders.