Who Should I Start? Joe Mixon or Omarion Hampton

Wednesday, January 21, 12:19 PM

Houston Texans general manager Nick Caserio said on Wednesday that running back Joe Mixon (foot, ankle) had a medical condition that never improved, according to Jonathan M. Alexander of the Houston Chronicle. "He didn't jump off a building. He wasn't doing anything irresponsible. It was a freak thing," Caserio said. The Texans were extremely vague with Mixon's injury all year, and he never ended up playing in 2025. Head coach DeMeco Ryans said on Monday that Mixon's status for the 2026 season is also uncertain due to his injury. Unexpectedly, the Texans struggled for consistent production out of their backfield with a mix of veteran Nick Chubb and Woody Marks. Marks took over halfway through the year and should be heavily involved again next season, even if Mixon returns. Needless to say, a lot of fantasy managers won't want anything to do with Mixon in 2026.

Sunday, January 11, 7:42 PM

Los Angeles Chargers rookie running back Omarion Hampton (ankle) is officially active for Sunday's playoff contest against the New England Patriots. He had been listed as questionable and missed a pair of practices before being upgraded to a limited participant on Friday. Hampton sat out Week 18 with an ankle injury, but his absence was more of a precaution as Los Angeles rested many starters, and the rookie running back was just four weeks removed from a seven-game absence. He took a little while to get back to 100 percent after the injury, but his 81% snap share and 22 touches from Week 17 should indicate that he's back to a starter's workload. We wouldn't be surprised to see him handle another 20-plus touches against the Patriots, whose run defense started to falter down the stretch but still finished with the third-fewest fantasy points allowed to opposing running backs in 2025.