Who Should I Start? Joe Mixon or Omarion Hampton

Thursday, November 20, 12:34 PM

Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

Thursday, November 20, 10:14 AM

Los Angeles Chargers rookie running back Omarion Hampton's practice window is expected to open after the Week 12 bye. Hampton (ankle) was placed on the injured reserve after suffering an ankle injury against the Washington Commanders. Head coach Jim Harbaugh shared that Hampton's activation window could open after the bye, but he was uncertain about a return in Week 13. When Hampton returns, he could enter a timeshare with standout Kimani Vidal, who's been excellent as his replacement. Hampton was starting to pick up steam in his rookie season, averaging 121.3 scrimmage yards and two touchdowns in his last three games when healthy. While a potential committee is in the works, and the Chargers' struggles with the offensive line, Hampton still offers elite upside once he returns.