Who Should I Start? Miles Sanders or James Cook

Friday, October 10, 5:02 PM

Dallas Cowboys running back Miles Sanders (ankle, knee) has been moved to season-ending injured reserve, according to Patrick Walker of the Dallas Cowboys. Sanders was limited in practice on Wednesday before missing Thursday's practice, but now his season is over as he deals with multiple injuries to his ankle and knee. The 28-year-old served as the primary backup running back to Javonte Williams over the first four games of the season before missing Week 5. Rookie Jaydon Blue was active in his place and should step into a larger role now with Sanders out. Blue shouldn't be in lineups for Week 6, but he is an interesting speculative pickup ahead of Sunday's game against the Panthers.

Saturday, December 27, 10:18 AM

Buffalo Bills running back James Cook was dominant in Week 16's win over the Cleveland Browns, totaling 134 scrimmage yards and two touchdowns on just 17 touches. Cook has ascended once again in the 2025 season, jumping from 79.2 scrimmage yards per game in 2024 to 121.3 this season. He currently leads the NFL in rushing yards and ranks RB6 in PPR formats. The Bills host the Philadelphia Eagles in Week 17, who have allowed the eighth-most fantasy points to running backs this season. While star defensive tackle Jalen Carter will be active this week for the Eagles, Cook and the Bills are running the ball with ease, so fantasy managers should expect more dominance from the fourth-year back.