Who Should I Start? Miles Sanders or James Cook

Friday, October 10, 5:02 PM

Dallas Cowboys running back Miles Sanders (ankle, knee) has been moved to season-ending injured reserve, according to Patrick Walker of the Dallas Cowboys. Sanders was limited in practice on Wednesday before missing Thursday's practice, but now his season is over as he deals with multiple injuries to his ankle and knee. The 28-year-old served as the primary backup running back to Javonte Williams over the first four games of the season before missing Week 5. Rookie Jaydon Blue was active in his place and should step into a larger role now with Sanders out. Blue shouldn't be in lineups for Week 6, but he is an interesting speculative pickup ahead of Sunday's game against the Panthers.

Saturday, November 8, 11:51 AM

Buffalo Bills running back James Cook has been removed from the injury report and will play Sunday against the Miami Dolphins, presumably without any limitations. This is great news for Cook and his fantasy managers, as a matchup against the Dolphins provides an enormous opportunity for the 26-year-old to rack up fantasy points. Miami has been miserable against the run this year, surrendering the third-most rushing yards and fifth-most fantasy points to opposing running backs in 2025. Cook is the overall RB7 in PPR leagues so far with 867 rushing yards, 100 receiving yards, and seven touchdowns. In his last outing against Miami, he accrued 118 scrimmage yards and one touchdown. Fantasy managers should have full confidence deploying Cook as a mid-to-high RB1 this week.