Who Should I Start? Darius Slayton or Justin Jefferson

Saturday, October 10, 8:06 AM

The Indianapolis Colts downgraded wide receiver Darius Slayton (knee) from questionable to out for their Week 5 contest on Sunday at the Pittsburgh Steelers. Slayton is dealing with a new knee injury, but he was able to practice on a limited basis on Friday. His next chance to make his Colts debut will come in Week 6 against the division-rival Tennessee Titans. Alec Pierce (heel) is on Injured Reserve, and veteran Keenan Allen (groin) is questionable to play this weekend, so Indy's receiving corps is thinned out behind Josh Downs. Laquon Treadwell and Deion Burks are the next men up in the Steel City in Week 5, so quarterback Daniel Jones will not be much of an upside play as a QB2 in two-QB superflex leagues against the Steelers. After being cut by the New York Giants, Slayton signed with the Colts on Sept. 21, but he has yet to play in a game with the team. The 29-year-old caught 37 passes for 538 yards and only one touchdown in 14 games in 2025 in his final season with the G-Men. The Colts' lack of WR depth is one of the reasons they have been mentioned as a potential suitor for Arizona Cardinals receiver Marvin Harrison Jr.