Who Should I Start? Samaje Perine or James Cook

Saturday, December 27, 11:25 AM

Cincinnati Bengals running back Samaje Perine scored a touchdown in the 45-21 win over the Miami Dolphins. While Chase Brown remains the No. 1 option out of the backfield, as expected, Perine has stayed involved by logging double-digit carries in two of his previous four appearances. With a favorable matchup against a weak, injury-plagued Cardinals defense on the horizon, everyone on the offensive side of the ball could benefit from a statistical standpoint. However, despite a higher ceiling than usual, Perine shouldn't be viewed as anything more than a deep-league desperation option in Week 17.

Saturday, December 27, 10:18 AM

Buffalo Bills running back James Cook was dominant in Week 16's win over the Cleveland Browns, totaling 134 scrimmage yards and two touchdowns on just 17 touches. Cook has ascended once again in the 2025 season, jumping from 79.2 scrimmage yards per game in 2024 to 121.3 this season. He currently leads the NFL in rushing yards and ranks RB6 in PPR formats. The Bills host the Philadelphia Eagles in Week 17, who have allowed the eighth-most fantasy points to running backs this season. While star defensive tackle Jalen Carter will be active this week for the Eagles, Cook and the Bills are running the ball with ease, so fantasy managers should expect more dominance from the fourth-year back.