Should I Start James Cook?

James Cook III Solidified Himself as a High-End Running Back in 2025

Friday, February 13, 7:31 AM

Buffalo Bills running back James Cook III solidified himself as one of the NFL's best running backs in 2025, racking up 1,621 rushing yards and 12 touchdowns on 309 carries across 17 games. The 26-year-old also impacted the game as a receiver, hauling in 33 receptions for 291 yards and two scores. Cook III has always been an efficient player, but he was able to reach new production heights in 2025 thanks to an increase in workload. After logging 239 touches across 16 games played in 2024, Cook III recorded 342 touches in 2025 and still averaged a highly efficient 5.6 yards per touch. Cook III signed a four-year extension with Buffalo before the start of the 2025 season, so he's locked in as the team's lead rusher for the foreseeable future. The Bills also promoted former offensive coordinator Joe Brady to head coach, so it seems unlikely that the team would radically shift its offensive approach going forward. Now that he's proven he can handle a significant workload, Cook III profiles as a high-end running back option for fantasy managers in dynasty formats.

Start Breece Hall or James Cook?

Start Kenneth Walker III or James Cook?

Start James Cook or Ashton Jeanty?

Start Alvin Kamara or James Cook?

Start James Conner or James Cook?

Start Joe Mixon or James Cook?

Start Aaron Jones Sr. or James Cook?

Start D'Andre Swift or James Cook?

Start Brian Robinson Jr. or James Cook?

Start Isiah Pacheco or James Cook?

Start Chuba Hubbard or James Cook?

Start James Cook or Quinshon Judkins?

Start James Cook or TreVeyon Henderson?

Start James Cook or Kaleb Johnson?

Start James Cook or Omarion Hampton?

Start Jaylen Warren or James Cook?

Start James Cook or RJ Harvey?

Start David Montgomery or James Cook?

Start James Cook or Jacory Croskey-Merritt?

Start James Cook or Tyrone Tracy Jr.?